The discriminative accuracy of total IgE was relatively modest for asthma, rhinitis and eczema (AUC [95% CI]: 0.72 [0.66-0.78], 0.70 [0.67-0.73], and 0.70 [0.64-0.76], respectively; Figure 3b, 3c, and 3d). This evidence concerns the gene IGHE and asthma.