Some of the SCNAs identified by CGH array as significantly associated with heavy alcohol consumption were matched with regions or genes frequently altered in HNSCC: 3p14 of FHIT, 8p23 of CSMD1, 9p21 of CDKN2A, 3q25-26 including CCNL1, PIK3CA, TP63 and DCUN1D1, and 11q13 including CCND1, CTTN and FADD [13-15]. Here, PIK3CA is linked to head and neck squamous cell carcinoma.