21 of 42 (50%) transcripts representing 14 of 29 (48%) validated human IK target genes were expressed at markedly higher levels in leukemic bone marrow specimens from B-lineage ALL/BPL patients, including most of the patients with BCR-ABL + /Ph+ ALL (Figure S2 in File S1; MANOVA, F1,748 = 168.7, P<0.0001). The gene discussed is IK; the disease is acute lymphoblastic leukemia.