IKZF1 and acute lymphoblastic leukemia: We used real-time qPCR to examine side-by-side genomic DNA from normal hematopoietic cells in normal bone marrow specimens (and primary leukemic cells from 32 pediatric patients with high-risk BPL, including 4 Ph+ ALL patients, for evidence of intragenic deletions of IKZF1. No Ph+ or Ph- high-risk BPL case was identified by interpatient comparisons or comparisons between leukemic and normal samples that had a significantly higher Ct value suggestive of an IKZF1 deletion.