In the present study, we have investigated the effects of rs7120118 variation on the expression of NR1H3, APOE, ABCA1 and ABCG1, the levels of soluble Aβ42, and β-secretase activity in a sample set containing inferior temporal cortex samples of neuropathologically examined subjects with AD pathology. The gene discussed is NR1H3; the disease is Alzheimer disease.