After searching HuGE Navigator, NCBI PubMed , EMBASE and Web of science using the keywords “Interleukin-23 receptor”, “IL-23 receptor”, “IL23R”, “polymorphism”, “variant”, “SNP”, “rs10889677”, “cancer”, or “tumor”, and found 5 studies (6731 cases and 7296 healthy controls), which fulfilled inclusion criteria [9-13]. The gene discussed is IL23R; the disease is neoplasm.