Five SNPs, GPX3 rs2070593 (p=0.002), GPX4 rs2074451 (p=0.046), SELS rs9874 (p=0.029), TXNRD1 rs17202060 (p=0.007) and TXNRD2 rs7322262 (p=0.025), significantly interacted with DOBS to alter breast cancer risk (Table 3). The gene discussed is GPX4; the disease is breast carcinoma.