Among others, OCI displays a distinct profile of antiviral cytokine expression in PBMC when compared to either CHC or healthy individuals, shows an antagonistic relation between HCV and IFN-α expression in PBMC, and that HCV replication in this compartment can be completely eliminated by activation of endogenous IFN-α [22], [23]. The gene discussed is IFNA1; the disease is cryohydrocytosis.