TP53 and neoplasm: Though Chang et al. [28] found that MSS diploid tumors had a lower p53 mutation rate and MSS aneuploid tumors had a higher p53 mutation rate, an observation that has been independently confirmed [2], we did not detect an association of p53 mutations or LOH of p53 with CIN status, tumor telomere length or type of telomere maintenance repair utilized by the tumor.