A striking observation in our study was that treatment with paclitaxel, although reducing primary tumor volume, increased significantly the number of metastatic nodules, angiogenesis (and VEGF and SDF-1 levels in tumor cells) and expression of ALDH, SOX2, CXCR4 and SDF-1 in vivo. The gene discussed is CXCL12; the disease is neoplasm.