CXCL1 and acute respiratory distress syndrome: In this study, we found LPS induced significant neutrophil infiltration in lung interstitial space and enhanced neutrophil migration by MPO activity assay, consistent with the observations that neutrophil migration is the featuring hallmark in the development of ALI induced by LPS [10], herein DPQ treatment diminished neutrophil recruitment in lung tissue which may due to the decreased expression of neutrophil chemokines of CXCL-1 and MIP-2.