The 10 Type I TFs were MYC, EP300, LMO2, FOXO1, EGR1, ZIC1, NR3C1, FOSB, GCGR, and STAT6. Of them, MYC, EP300, and LMO2 are annotated as cancer genes in “Cancer Gene Census” (http://www.sanger.ac.uk/genetics/CGP/Census/). The gene discussed is ZIC1; the disease is cancer.