Two tumor suppressors (GADD45G and INHBB) were reported to be downregulated and several oncogenes (TP63 and genes encoding two calcium-binding proteins) were found to be upregulated in breast cancer cells after pre-miR-196a-C introduction, suggestive of the oncogenic activity of pre-miR-196a-C and protective role of pre-miR-196a-T [83], [128]. The gene discussed is INHBB; the disease is breast cancer.