INS and Hyperglycemia: At P6, after 3 consecutive days of hyperglycemia, STZ injection resulted in a significant decrease in circulating insulin in STZ animals when compared to control group (0.32+/−0.07; n = 10 vs 0.17+/−0.01; n = 15, unpaired t-test, p = 0.02) (Fig. 1B).