INS and Hyperglycemia: In a population of extremely low birth weight infants who did not receive insulin therapy, Mohamed et al. showed that infants with ROP experienced a greater mean number of days with hyperglycemia defined as whole blood glucose >150 mg/dl (7 days vs. 2 days, p = <0.0001); each day of hyperglycemia increased the risk of ROP by 7% [11].