In secondary analyses, application of the same logistic models showed that overweight white individuals homozygous for the NOS3 894T allele did not incur a significant risk of diabetes when compared to carriers of two G alleles, and there was no association between the TT genotype and susceptibility to diabetes in those whose BMI was <25 kg/m2 (data not shown). The gene discussed is NOS3; the disease is diabetes mellitus.