The dominance of β-catenin-induced crypt proliferation in response to CR infection was further validated in a Castaneus strain (CAST.11M) that exhibits high susceptibility to Anthrax’s lethal toxin (LT) [47] due to a region at chromosome 11 that encodes the LT-responsive CAST/Ei allele of Nlrp1b inflammasome [47]. This evidence concerns the gene CAST and infection.