NFKB1 and colitis: Ongoing studies from our laboratory have further demonstrated that functional cross-talk between Wnt/β-catenin and Notch [37] and Notch and NF-κB [38] pathways regulate crypt hyperplasia and/or tumorigenesis in response to CR infection in outbred mice while inflammation and/or colitis in the inbred mice, driven by the expression of distinct cytokines/chemokines, is regulated by activation of the MEK/ERK/NF-κB pathways [39].