In addition, a study on Jaagsiekte retrovirus (JSRV) found that although the soluble form of its receptor, Hyal2 (sHyal2), did not mediate the entrance of a JSRV-pseudotype retroviral vector into cells lacking the integrated Hyal2, this purified soluble protein significantly inhibited the infection of the pseudotyped vector in the target cells of JSRV [13]. The gene discussed is HYAL2; the disease is infection.