Our results indicate genetic susceptibility at the MMP-1 gene that could have potential applicability in oral squamous cell carcinomas; however, based on the National Cancer Institute Clinical Trial information database, MMP-1 inhibition has never been used in oral cancer therapy (http://www.cancer.gov/clinicaltrials/search/results?protocolsearchid=8196085). This evidence concerns the gene MMP1 and oral cavity squamous cell carcinoma.