Elevated levels of ATX are also associated with other diseases including multiple fibrotic diseases such as idiopathic pulmonary fibrosis and scleroderma, rheumatoid arthritis, chronic liver disease, obesity, multiple sclerosis, Alzheimer's disease, neuropathic pain, and primary open angle glaucoma [5], [12], [13]. This evidence concerns the gene ENPP2 and idiopathic pulmonary fibrosis.