SIRT1 and neoplasm: However, in the Sirt1-depleted xenografts, the inhibitory effects of Res on tumor growth were rescued (Res+Si vs Res+Ci: 1.2313±0.1777 cm3 vs 0.68±0.0672 cm3, P<0.001, Res+Si vs control: 1.2313±0.1777 cm3 vs 1.4288±0.1741 cm3, P = 0.123) (Figure 5A).