In regions within 1 kb of DUX4-bound sites (both bound repetitive elements and unique sites), ratios of expression in FSHD myotubes versus controls are well-correlated with the activation levels we found in lenti-DUX4 transduced myoblasts (Figure 7A, Spearman's rho = 0.38, p<10−15). The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.