SUMO2 and viral infectious disease: Notably, since SUMO-2 signaling is only activated due to extracellular stress, LANA may possess a unique SUMO-2 instead of SUMO-1 interacting motif to usurp the host SUMOylation pathway by mimicking stress signaling (This could be the reason why LANASIM greatly associates with certain target proteins instead of others with SUMO-2 modification), thus creating a cellular environment favorable for viral infection.