MRC1 and neoplasm: Multivariate analysis involving sex, age, Astler-Coller stage, tumor grade, tumor site, TS expression, the p21WAF1/p53 immunophenotype and loss of MMR protein expression identified Astler-Coller stage, high TS expression and the p21WAF1+/p53- immunophenotype as independent factors associated with DFS and OS (Table 2).