The results obtained in our limited series of 28 cases were confirmed by a paired comparison of expression for the CHGA, SYP and VGF genes performed in a publicly available dataset of 103 aggressive breast carcinomas [18] where 10 % of cases showed gene overexpression of at least one NE marker (detection p < 0.01 and Log(2) signal > 9) and showed that there is only a partial correlation among these three markers, CHGA expression being often unrelated with that of SYP and VGF. This evidence concerns the gene SYP and breast carcinoma.