Indeed, CXCL8 has been shown to be down-regulated in response to sulindac and has been identified as a mediator of sulindac-induced apoptosis in colorectal cancer cell line models [131], while salicylate-treatment results in the down-regulation of CXCL8 expression in the macrophage-like cell line THP-1 [132]. The gene discussed is CXCL8; the disease is colorectal cancer.