Given the central role of CXCL8 in many of the hallmarks of cancer, it is likely that the inhibition of CXCL8 signaling is a contributing factor to the effects of curcumin on cancer cell survival, angiogenesis and metastasis, as well as the reported ability of curcumin to sensitize tumor cells to the effects of chemotherapy and radiotherapy [114]. The gene discussed is CXCL8; the disease is neoplasm.