NFKB1 and cancer: In particular, NFκB contributes to the initiation and progression of a wide variety of human cancers, through the regulation of genes that are involved in angiogenesis (e.g., CXCL8, VEGF), proliferation (e.g., cyclin D1), evasion of apoptosis (e.g., Bcl-2) and metastasis (e.g., MMP9) [101].