For example, anti-CXCL8 antibodies have been used to impede the growth of PC3 tumors in SCID mice by reducing angiogenic signaling [59] and have been shown to diminish angiogenesis in orthotopic prostate carcinomas in NOD-SCID mice, as a result of impaired neutrophil infiltration [133]. This evidence concerns the gene CXCL8 and prostate carcinoma.