Understanding the correlation between oncogenes, tumor suppressors and the regulation of CXCL8 (or CXCL1, CXCL5 or CXCL6) expression will have important consequences for developing stratified or personalized therapeutic strategies wherein the genetic background of tumors can be used to select appropriate patients in which the exploitation of CXCL8 signaling-inhibitors is most likely to show clinical benefit. The gene discussed is CXCL5; the disease is neoplasm.