In addition, folate could mediate a cell or tissue specific gene silencing, when it was conjugated to liposomes to knockdown the proto-oncogene MYCN. A preliminary study with severe combined immune deficient (SCID) mice bearing a LA-N-5 xenografted tumor demonstrated a receptor-mediated uptake of the liposome-siMYCN folic acid complex and consequently 53.1% knockdown of mRNA expression in tumor tissue [116]. This evidence concerns the gene MYCN and neoplasm.