Based on the initial detection of Cav2.3 transcripts in the insulinoma cell line INS-1 [70,73], additional investigations were performed with Cav2.3-deficient mice, which showed disturbance not only of glucose-induced insulin release [72,75], but also of glucose-mediated glucagon suppression [74], and more important even disturbances of glucose-mediated somatostatin-release [80]. Here, CACNA1E is linked to pancreatic insulinoma.