Magoori et al (30) reported that ApoE and LRP-5 double knockout mice developed more severe hypercholesterolemia than ApoE−/− mice and that this hypercholesterolemia resulted mainly from an increased level of ApoB-48-containing lipoproteins in the plasma, wheras LRP-5 single knockout mice showed no significant difference in plasma cholesterol levels. This evidence concerns the gene APOE and familial hypercholesterolemia.