BRAF and metastatic melanoma: In a phase III open-label clinical trial (METRIC) [65] trametinib was shown to significantly improve rates of progression-free and overall survival compared with chemotherapy with dacarbazine or paclitaxel (6 month overall survival of 81% and 67% respectively, patient crossover included, p = 0.01), in patients with V600E or V600K BRAF mutation-positive metastatic melanoma.