Polymorphisms in multiple genes have been reported to be associated with COPD [87], such as transcription factor [e.g. nuclear factor-kappa B (NFκB)] [88], extracellular matrix (e.g., matrix metalloproteinase-12 (MMP-12)) [89,90], cytokines [e.g. tumor necrosis factor (TNF)-α] [91], chemokines [e.g. interleukins (IL)-8, IL-8 receptor and chemokine receptor (CCR)1] [92,93], and apoptosis (e.g., caspase-3 and vascular endothelial growth factor (VEGF)) [94,95]. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.