RNAi screens targeting 19,121 human transcripts also identified a critical role for the PAF1 complex in HIV down-regulation, where siRNA knockdown of the PAF1 family of proteins enhanced HIV-1 reverse transcription and integration of provirus while over expression of PAF1 made cells recalcitrant to HIV-1 and 2 infections [102]. The gene discussed is PAF1; the disease is infection.