AKT1 and glioblastoma: Furthermore, overexpression of miR-7, a miRNA involved in the repression of the pro-oncogenic Akt pathway, reduced the proliferation and invasion in different GBM cell lines and in one GBM stem cell line [128], while expression of miR-128 inhibited the proliferation of glioma cells by decreasing the levels of E2F3a [129].