By promoting the downregulation of the DNA methyltransferases 3A and B (DNMT3A and 3B), miR-29 induces re-expression of methylation-silenced tumor suppressor genes, such as the fragile histidine triad protein (FHIT) and the WW domain containing oxidoreductase (WWOX) [49]. This evidence concerns the gene WWOX and neoplasm.