Lee and colleagues took advantage of the abundant expression of the enzyme telomerase reverse transcriptase (hTERT) in cancer cells and developed a multimodal GBM-targeting approach, combining hTERT-targeting ribozyme-controlled HSV-tk expression with overexpression of miR-145, a miRNA that is usually downregulated in GBM [144]. This evidence concerns the gene TKT and glioblastoma.