By contrast, R1441C appeared to increase LRRK2-tubulin interactions by ∼25%, whereas a LRRK2 variant not segregating with PD (R1514Q) (53) showed no significant effect on the interaction between LRRK2 and TUBB/TUBB4 (Fig. 8, A and B). This evidence concerns the gene TUBB3 and Parkinson disease.