MKI67 and neoplasm: On univariate survival analysis, tumour grade (HR 1.89, 95% CI 1.12-3.17, P = 0.017), lymph node involvement (HR 2.42, 95% CI 1.55-3.76, P < 0.001), HER-2 status (HR 2.90, 95% CI 1.25-6.72, P = 0.013), Ki-67 proliferative activity (HR 3.01, 95% CI 1.50-6.04, P = 0.002), lymphovascular invasion (HR 3.83, 95% CI 1.89-7.77, P ≤ 0.001), microvessel density (HR 1.70, 95% CI 1.05-2.73, P = 0.030) and systemic treatment (HR 1.59, 95% CI 1.09-2.32, P = 0.017) were significantly associated with recurrence- free survival.