The different Hp phenotypes influence the progression of various infectious and inflammatory diseases, including malaria, due to their phenotype-dependent binding affinity to Hb (Hp1-1 > Hp2-1 > Hp2-2) and the CD163 receptor on monocytes and macrophages (Hp2-2 > Hp2-1 > Hp1-1) [11]. This evidence concerns the gene CD163 and malaria.