Erroneously, all to date known genes that are related to pheochromocytomas and paragangliomas were sequenced, including multiplex ligation-dependent probe amplification (MLPA) to detect larger deletions (RET, MAX, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127 and VHL; MRC-Holland kit P226-B2), but none showed pathogenic mutations in their coding sequence or splice sites. This evidence concerns the gene VHL and paraganglioma.