Here, we investigated the genotype and allele distribution of SNPs in the promoter regions of several genes with inflammatory modulatory activity such as VEGF, Alpha-1-Antichymotripsin (ACT), hydroxy-methyl-glutaryl CoA reductase (HMG-CR), Interferon Gamma (INF-γ), IL-1ß, IL-10, IL-6, and TNF-α from ethnical homogeneous young patients with periodontitis. The gene discussed is HMGCR; the disease is periodontitis.