Notably, periostin expression is well correlated with malignant behavior, including growth, invasion, angiogenesis, metastasis and poor survival in ovarian cancer (5), cholangiocarcinoma (10), breast cancer (11), colon cancer (12), esophageal cancer (14) and pancreatic ductal ADC (15). The gene discussed is POSTN; the disease is malignant colon neoplasm.