TNFSF12 and Cerebral ischemia: Studies with an in vitro model of hypoxia and an in vivo model of cerebral ischemia demonstrated that either treatment with sub-lethal doses of TWEAK, or induction of endogenous of TWEAK and Fn14 expression with sub-lethal hypoxia, renders neurons tolerant to a lethal hypoxic or ischemic injury applied 24 h later.