Evaluating the PLC (adrenaline, noradrenaline, and its metabolites) has not been proven to be useful for the staging or diagnosis of CAN, although PLC has a remarkable role in the differential diagnosis of other endocrine pathologies such as pheochromocytoma and medullary adrenal insufficiency. This evidence concerns the gene HSPG2 and hereditary pheochromocytoma-paraganglioma.