It is now well understood that imbalance of actions induced by ANG II and its smaller metabolites, ANG (1–7), ANG III, and ANG IV in favoring increases in tissue ANG II formation and the activation of the ACE/ANG II/AT1 receptor axis may lead to the development of hypertension and ANG II-induced target organ injury and diseases. The gene discussed is AGT; the disease is hypertensive disorder.