Another point is that GAT1 is mostly in terminals where it recycles GABA, and GAT1 deletion leads to decreased quantal GABA release, and a differential tonic activation of GABA(A) versus GABA(B) receptors in the hippocampus (241), as well as to tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum (242). The gene discussed is SLC6A1; the disease is Tremor.