TP53 and familial pancreatic carcinoma: Conditional expression of mutant K-ras (constitutively active mutation G12D) and mutant p53 (inactivating mutation R172H) in mice pancreas recapitulates pancreatic cancer development, which shows a progression pattern similar to that of human pancreatic cancer such as liver metastasis and desmoplasia (Hingorani et al., 2005).