GRIN2B and neurodevelopmental disorder: Curiously, the only described de novoaberration within the NR2B C-terminus was detected in an apparently healthy control subject,29 whereas all known pathogenic GRIN2B mutationscausing neurodevelopmental disorders are found within the N-terminal region, ligand-binding S1 andS2 segments, and the re-entrant pore-forming loop (see Fig1).8,13–18 This suggests that pathogenic mutationsaffecting key functional motifs have a greater impact on protein function and can negativelyinfluence neurodevelopment and brain excitability.