Tumor masses arising in mice treated with hERG1 blockers displayed a strong decrease of the total vascular area per microscopic field (Fig. 6F, graph on the right), accompanied by a higher degree of perivascular fibrosis (see arrows in Fig. 6F), as well as by a decrease of pAkt levels, and a lower HIF-1α expression (Fig. 6E and Fig. 6SDA for densitometric analysis), compared to those in control mice. The gene discussed is KCNH2; the disease is neoplasm.