Since previous studies indicate that NDRG1 participates in the growth, migration, invasion, and angiogenesis of cancer cells [24, 25], and combining the evidence that FOXD3 directly regulated the expression of NDRG1, we further investigated the effects of FOXD3 over-expression and NDRG1 restoration on cultured NB cells. The gene discussed is NDRG1; the disease is neuroblastoma.