Through a series of deletion of the promoter of NDRG1 luciferase constructs, we found that the +41 to +69 bp region was essential for the promoter activities of NDRG1 in NB cells, while mutation of the FOXD3 binding site within this region abrogated the promoter activities of NDRG1. The gene discussed is FOXD3; the disease is neuroblastoma.