Mining the publicly available clinical tumor expression data sets [R2: microarray analysis and visualization platform (http://r2.amc.nl)] revealed the altered FOXD3 transcript levels in some kinds of cancer, including down-regulation in colon cancer and cervix cancer, and up-regulation in renal cancer and endometrial cancer (Figure S1A), suggesting the potential roles of FOXD3 in tumorigenesis. The gene discussed is FOXD3; the disease is renal carcinoma.