In contrast, the transcript levels of several potential target genes bearing the FOXD3 binding sites within their promoters, including B-cell CLL/lymphoma 2 (BCL2), programmed cell death 4 (PDCD4), platelet derived growth factor C (PDGFC), and matrix metallopeptidase 14 (MMP-14), were not affected by stable over-expression or knockdown of FOXD3 in NB cells (Figure S4). The gene discussed is FOXD3; the disease is neuroblastoma.