ACVRL1 and arteriovenous hemangioma/malformation: Because RASA1 mutations have previously been associated with capillary and arteriovenous malformations similar to the HHT phenotype ([20][21]), and because no variants were identified in the ENG, ACVRL1, or SMAD4 genes, the RASA1 variant was assumed to be the causative mutation for this sample.