In addition, EGF could stimulate tumour cells to produce a variety of inflammatory factors, such as interleukin (IL)-8 (CXCL8), chemokine legend (CXCL)-12, IL-6 and IL-1, to chemo-attract tumour cells and leucocytes, such as monocytes, neutrophils, or lymphocytes, from the circulation to tumour tissues, contributing to the formation of inflammatory environment 12,13. This evidence concerns the gene IL6 and neoplasm.