It indicates that EGF may initiate and contribute to the development of HCC inflammatory microenvironment by the production of leucocyte chemo-attractants like CXCL5 and CXCL8 from HCC per se, probably responsible for the movement of tumour cells and recruitment of circulating leucocytes into the certain location 29. This evidence concerns the gene CXCL8 and hepatocellular carcinoma.