Immune deficient mice have acquired severe liver disease through the transgenic overexpression of urokinase-type plasminogen activator in uPA+/+-SCID mice or a knockout of fumarylacetoacetate hydrolase (FAH) in FRG (Fah-/-Rag2-/-IL2-Rg-/-) mice [9-13]. Here, PLAU is linked to liver disorder.