We first downloaded 15 breast cancer related genes from the Cancer Gene Census[31]: AKT1, BAP1, BRCA2, CCND1, CDH1, EP300, ERBB2, ETV6, GATA3, MAP2K4, NTRK3, PBRM1, PIK3CA, RB1, and TP53. The gene discussed is RB1; the disease is breast cancer.