To conclude, we have developed a robust α-synuclein mouse model by means of rAAV2/7-vector delivery which recapitulates several indispensable features of a PD animal model: motor deficits, robust and progressive nigral dopaminergic neuron loss over time and the presence of α-synuclein-rich inclusions in the surviving cell bodies. This evidence concerns the gene SNCA and Parkinson disease.